The Tans Lab

Biophysics @ AMOLF Amsterdam

About the group

We study the dynamics of single proteins and single cells in organoids using novel experimental approaches.

The group is based at the AMOLF institute in Amsterdam, and is part of the Autonomous Matter department. It is headed by Sander Tans, who is also affiliated with Delft University of Technology, and the Kavli institute of Nanoscience

We’re always looking for talented students/postdocs. If you are interested in joining our team, view our open positions or send us an e-mail to s.tans@amolf.nl.

NEWS

  • In October 2022, Sander was awarded an ERC Synergy Grant, together with researchers from Heidelberg and ETH Z├╝rich.
  • 2021 started well for Florian with a beautiful paper in Science about ribosome-driven assembly of protein complexes.
  • We congratulate Mario with his paper in Nature on protein disaggregation that was published in 2020. Also check out the movie we made about it.
  • Another exciting Nature publication from our lab appeared in 2020 about how motility can drive bacterial coexistence. Here is a link to the press release.

Single-molecule

How can one protein fold another?

This intriguing question underlies all biological activity, and numerous ageing-related diseases. Recent technical breakthroughs are now making it possible to address it, by directly following the movements and forces of single protein chains within a chaperone complex.

We have pioneered the use of optical tweezers to study these dynamics of individual protein-chaperone complexes, and are currently exploiting a new range of possibilities afforded by simultaneous single-molecule fluorescence.

Key Publications

Organoids

How do tissues self-organize?

At the cellular level, we use time-lapse microscopy and image analysis to understand how multi-cellular systems self-organise, with a specific recent interest in organoids. We have developed AI-driven cell tracking and cell type inference approaches, and use these to mainly study the intestinal epithelium, often in collaboration with other groups. All our organoid work is done together with my colleague Jeroen van Zon, who runs his group also here at the AMOLF institute.

Key Publications

Join us

Our open positions are available at the institute website. You can also contact us.